The body ’s resistant system plays a function in Parkinson ’s disease , a new study discover . In the journalNature , scientists from Columbia University Medical Center and the La Jolla Institute for Allergy and Immunology in California write that protein in the brain associated with Parkinson ’s gun trigger an autoimmune response , spark off the resistant cells known as T cells .
With Parkinson ’s disease , the head slowly stops raise Intropin , degrading the patient ’s power to controlmuscle movements(leading totremors , shaking , and rigidity ) . This report suggest that damage alpha - synuclein proteins mark T cadre into thinking that Dopastat neurons are foreign invader . " The approximation that a misfunction immune arrangement contributes to Parkinson ’s date back almost 100 year , " study co - leader David Sulzer of Columbia Medical Center excuse in apress statement . " But until now , no one has been able to join the battery-acid . Our findings show that two fragments of alpha - synuclein , a protein that pile up in the brain cells of people with Parkinson ’s , can set off the tetraiodothyronine prison cell involved in autoimmune attack . "
The survey examine blood samples from 67 Parkinson ’s patients and 36 tidy mastery subjects , testing the resistant response to fragments of unlike proteins find oneself in neuron , let in alpha - synuclein . The researchers found that while the blood samples in the ascendance mathematical group did n’t show any immune response to the protein fragments , those from the Parkinson ’s patients showed T electric cell which had an oversize response to the protein . This autoimmune response could be triggered by the brain ’s decreased ability to get disembarrass of unnatural alpha - synuclein protein in Parkinson ’s disease . The body then sees the unusual aggregation of these damaged proteins as an attack from a pathogen .
These findings open up up new possibilities for Parkinson ’s treatments . Immunotherapy that changes the body ’s response to alpha - synuclein could potentially improve symptom .
